| 摘要 |
【摘要】目的：探究青少年首发抑郁症血清肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)、白细胞介素13(interleukin 13, IL-13)与躯体化症状的相关性。方法：依照纳入及排除标准收集我院在2022年1月-2023年1月进行治疗的120例青少年首发抑郁症病人作为疾病组，另选取同期健康体检人员90例作为健康组，空腹采取健康组和疾病组5ml外周静脉血，室温静置半小时后，通过离心机以4000r/min的速度进行10min离心，取上层清液，酶联免疫吸附测定法检测血清TNF-α、IL-13水平，对比健康组和疾病组的血清TNF-α、IL-13水平，之后根据是否伴随有躯体化症状，对比不同躯体化病人与无躯体化病人血清TNF-α、IL-13水平，并分析TNF-α、IL-13水平与躯体化的相关性。结果：健康组的血清TNF-α、IL-13水平明显小于疾病组（P＜0.05），出现躯体化症状的共有99例，占82.50%，出现失眠、头晕、耳鸣、消化道症状、心悸、出汗、尿频、体重下降症状的躯体化病人血清TNF-α、IL-13水平明显大于未出现躯体化症状的病人，血清TNF-α水平与头晕、耳鸣、出汗存在显著正相关，而血清IL-13水平与耳鸣、消化道症状、心悸、体重下降存在显著正相关。结论：青少年首发抑郁症的血清TNF-α、IL-13水平升高，伴随躯体症状的抑郁症病人血清TNF-α、IL-13水平会出现进一步升高，血清TNF-α水平与头晕、耳鸣、出汗存在显著正相关，而血清IL-13水平与耳鸣、消化道症状、心悸、体重下降存在显著正相关。
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| Abstract |
[Abstract] Objective: To explore the serum tumor necrosis factor in adolescent first-episode depression- α (tumor crossing factor)- α, TNF-α)、 The correlation between interleukin-13 (IL-13) and somatization symptoms. Methods: According to the inclusion and exclusion criteria, 120 adolescent first-episode depression patients treated in our hospital from January 2022 to January 2023 were collected as the disease group. In addition, 90 health examination personnel in the same period were selected as the health group. 5ml of peripheral venous blood was taken from the health group and the disease group on an empty stomach, and left at room temperature for half an hour. After centrifugation at a speed of 4000r/min for 10 minutes, the supernatant was taken, and serum TNF was detected by enzyme-linked immunosorbent assay- α、 IL-13 levels, comparing serum TNF levels between healthy and diseased groups- α、 IL-13 level, and then compare the serum TNF levels between different somatized and non somatized patients based on whether they are accompanied by somatization symptoms- α、 IL-13 levels and analysis of TNF- α、 The correlation between IL-13 levels and somatization. Results: Serum TNF in the healthy group- α、The IL-13 level was significantly lower than that of the disease group (P<0.05), with a total of 99 cases (82.50%) experiencing somatization symptoms. The serum TNF of somatization patients with insomnia, dizziness, tinnitus, gastrointestinal symptoms, palpitations, sweating, frequent urination, and weight loss symptoms- α、 The IL-13 level is significantly higher than that of patients without somatization symptoms, and the serum TNF- α There is a significant positive correlation between levels and dizziness, tinnitus, and sweating, while serum IL-13 levels are significantly positively correlated with tinnitus, gastrointestinal symptoms, palpitations, and weight loss. Conclusion: Serum TNF in adolescents with first-episode depression- α、Elevated IL-13 levels and serum TNF in depression patients with somatic symptoms- α、Further increase in IL-13 levels and serum TNF- α There is a significant positive correlation between levels and dizziness, tinnitus, and sweating, while serum IL-13 levels are significantly positively correlated with tinnitus, gastrointestinal symptoms, palpitations, and weight loss.
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