穿心莲内酯的提纯工艺及药理作用研究进展

Research progress on extraction technology and pharmacological effect of Andrographolide

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DOI 10.12208/j.ijmd.20240024
刊名
International Journal of Medicine and Data
年,卷(期) 2024, 8(3)
作者
作者单位

黑龙江八一农垦大学生命科学技术学院 黑龙江大庆 ;
;

摘要
中草药穿心莲是爵床科穿心莲属的一年生草本植物,常用于治疗菌痢、消化不良、毒蛇咬伤以及神经性皮炎等病症。穿心莲内酯是一种从穿心莲中提取分离出的二萜内酯类化合物。近年来随着化学和网络药理学的研究不断深入,发现穿心莲内酯具有良好的抗菌、抗炎、以及抗氧化等药理作用。因其良好的药理活性,穿心莲内酯的提纯工艺与含量测定方法也受到广大学者的高度关注。本文对穿心莲内酯的提纯工艺,含量测定方法及其药理作用进行综述,旨在为穿心莲内酯的后续研究及其相关药物的开发应用提供新思路。
Abstract
The Chinese herbal medicine Andrographis Paniculata is an annual herb of the genus Andrographis in the family Acanthaceae. It is often used to treat bacillary dysentery, dyspepsia, snake bites, and neurodermatitis. Andrographolide is a kind of diterpenoid lactone compound extracted and isolated from Andrographolide. In recent years, with the deepening of chemical and network pharmacology research, it has been found that Andrographolide has good anti-bacterial, anti-inflammatory, anti-oxidant and other pharmacological effects. Because of its good pharmacological activity, the purification process and content determination method of Andrographolide have been highly concerned by many scholars. This article reviews the purification process, content determination method and pharmacological action of Andrographolide in order to provide new ideas for further research on Andrographolide and the development and application of related drugs.
关键词
穿心莲内酯;提纯工艺;含量测定;药理作用
KeyWord
Andrographolide; Purification technology; Content determination; Pharmacological activity
基金项目
页码 1-4
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王安琪,侯文爽,权泉,黄曦醇,李君豪,金成浩*. 穿心莲内酯的提纯工艺及药理作用研究进展 [J]. 国际医学与数据杂志. 2024; 8; (3). 1 - 4.

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