International Journal of Clinical Research

The core feature of Non-Cirrhotic Portal Hypertension (NCPH) is elevated pressure in the portal venous system, with common complications including splenomegaly, esophageal and gastric varices, and ascites. The association of NCPH with pregnancy is a rare occurrence, and the combination of NCPH with HELLP syndrome is even less common. Hemodynamic changes during pregnancy, the worsening of portal hypertension, and multi-system damage caused by HELLP syndrome collectively exacerbate the patients condition and significantly increase the risk of perinatal complications and mortality. Due to the lack of broader research and standardized clinical practice guidelines, the diagnosis and management of this condition pose challenges for gastroenterologists, hepatologists, and obstetricians. Here, we share a case of partial HELLP syndrome occurring on the basis of NCPH to enhance physicians awareness and attention to such diseases.

HELLP syndrome; Non-cirrhotic portal hypertension; Pregnancy; Perinatal mortality