International Journal of Clinical Research

Objective To explore the effect of using sodium bicarbonate solution to gargle after glucocorticoid aerosol treatment to prevent oral leukoplakia. Methods A total of 78 patients with respiratory diseases who used glucocorticoid aerosol inhalation through the mouth from July 1, 2021 to December 31, 2023 were selected. The control group used warm water gargle, and the experimental group used 2.5% sodium bicarbonate solution and 5% sodium bicarbonate solution to gargle. The nursing effect was compared, the incidence of oral leukoplakia and the changes in oral pH value were statistically analyzed, and the differences between the data were observed. Results According to statistics, the incidence of white spots in the control group was 6 (40.00%), the incidence of white spots in the 2.5% sodium bicarbonate solution was 7 (30.43%), and the incidence of white spots in the 5% sodium bicarbonate solution was 4 (10.00%). It can be seen that the incidence of white spots in the sodium bicarbonate solution group was lower than that in the control group (P < 0.05). In addition, the incidence of white spots in the 5% sodium bicarbonate solution was significantly lower than that in the 2.5% sodium bicarbonate solution (P < 0.05); the change in oral pH value showed that the sodium bicarbonate solution group was higher than the control group. Conclusion After glucocorticoid atomization treatment, the use of sodium bicarbonate solution to rinse the mouth can effectively prevent the occurrence of oral white spots, improve the oral acidic microenvironment, and avoid the occurrence of fungal infections. It is worthy of promotion and application.

Glucocorticoid atomization; Sodium bicarbonate solution; Oral white spots; Fungal infection