International Journal of Clinical Research

Tubulin-tyrosine ligase-like protein 12 (TTLL12) is an important member of the tubulin tyrosine ligase family (TTLL), which is jointly responsible for the post-translational modification of tubulin and has received increasing attention for its role in cancer. TTLL12 is upregulated in a variety of cancers and is associated with poor prognosis. Studies have shown that TTLL12 may be associated with human cancer progression by affecting the formation of nitrotyrosine. Abnormal expression of TTLL12 may promote the growth and spread of tumor cells by interfering with the normal function of microtubules. This review aims to summarize the research progress, biological functions, and possible carcinogenic mechanisms of TTLL12 in various cancers based on existing studies at home and abroad, and summarize its possibility as a potential molecular marker and therapeutic target. In-depth research on TTLL12 may provide new molecular targets for cancer diagnosis, prognosis assessment and treatment. In the future, it is necessary to further explore the specific mechanism of action of TTLL12, as well as its expression pattern and functional differences in different cancers, to promote the development of personalized treatment strategies.

TTLL12; Microtubule protein; Nitrotyrosine; Cancer; Biomarker