International Journal of Clinical Research

Objective To analyze the clinical effect of glucocorticoids combined with immunosuppressants in the treatment of rheumatic renal diseases in children. Methods The samples of the experiment were all children with rheumatic renal diseases admitted to our hospital from January 2023 to January 2024, with a total of 82 cases. The participants were divided into two groups by computer random grouping, namely the control group (immunosuppressant treatment) and the observation group (glucocorticoids combined with immunosuppressant treatment). The relevant index data of the two groups of children were sorted and recorded during the implementation process, and compared and observed with the statistical system to analyze the application value of glucocorticoids combined with immunosuppressants in the treatment intervention. Results The C-reactive protein score, interleukin-1 score and symptom improvement time of the children in the observation group were lower than those of the other group. The total treatment efficiency and quality of life data showed a higher advantage than the other group. The inter-group comparison P value was ﹤0.05, which was statistically significant. Conclusion The combined use of glucocorticoids and immunosuppressants in children with rheumatic renal diseases can significantly relieve inflammatory responses, shorten the improvement time, promote the improvement of efficacy, and maintain the quality of life. The overall effect is definite and suitable for promotion.

Glucocorticoids; Immunosuppressants; Children; Rheumatic renal diseases; Clinical analysis