International Journal of Clinical Research

Objective To analyze the therapeutic effect of irbesartan combined with nitroprusside in patients with hypertension and heart failure. Methods The subjects of this study were 56 patients with hypertension and heart failure, and the sampling period was from January 2022 to January 2023. Divided into a reference group and an experimental group using a random number table method, with 28 cases in each group. The reference group received treatment with nitroprusside, while the experimental group received treatment with irbesartan based on the above. Compare the therapeutic effects of two groups. Results The difference in blood pressure and heart rate indicators between the two groups before treatment was small (P>0.05), and after treatment, the experimental group was lower than the reference group (P<0.05). The endothelial function of the experimental group was better than that of the reference group (P<0.05). Conclusion The combination of irbesartan and nitroprusside can achieve significant therapeutic effects in patients with hypertension and heart failure, and can significantly improve their blood pressure, heart rate indicators, and endothelial function. This method is worth promoting in clinical practice.

Hypertension; Heart failure; Irbesartan; Sodium nitroprusside; Blood pressure; Heart rate; Endothelial function