International Journal of Clinical Research

Objective To observe and analyze the clinical effect and application value of Shenqi Dihuang Decoction combined with dapagliflozin in the treatment of patients with diabetic nephropathy. Methods A retrospective study method was used to select 60 patients with diabetic nephropathy who were treated in the hospital (sample inclusion number: 60 cases; sample inclusion time: May 2023 to May 2024). They were divided into two groups, control and experimental, based on the random ball-drawing method, and the number of observation cases was highly consistent. Dapagliflozin treatment and Shenqi Dihuang Decoction combined with dapagliflozin treatment were implemented respectively. The treatment effects were collected and analyzed. Results Compared with the control group (dapagliflozin treatment), the experimental group (Shenqi Dihuang Decoction combined with dapagliflozin treatment) had lower blood sugar indexes (fasting blood sugar/2h postprandial blood sugar/glycosylated hemoglobin), lower renal function indexes (serum creatinine/uric acid/cystatin C), lower inflammatory factor indexes (interleukin 6/tumor necrosis factor α/high-sensitivity C-reactive protein), and lower incidence of adverse reactions after treatment, and the differences were statistically significant (P<0.05). Conclusion Shenqi Dihuang Decoction combined with dapagliflozin treatment can effectively reduce the incidence of adverse reactions in patients with diabetic nephropathy, relieve symptoms, inhibit inflammatory response, improve blood sugar control, and promote renal function recovery, and has a high application value.

Diabetic nephropathy; Shenqi Dihuang Decoction; Dapagliflozin; Therapeutic effect