Advances in International Psychology

Autism spectrum Disorder (ASD) is a common neurodevelopmental disorder that affects the neurodevelopment of approximately 3% of school-age children. Its core symptoms are social communication disorders and repetitive stereotypical behaviors. Autism seriously affects childrens mental health, social and learning ability, but also brings a heavy burden on the family and society. The cause of autism is mainly related to genetic factors, Chromodomain-helicase-DNA-binding protein 8 (CHD8) is one of the high confidence risk genes for ASD. This paper summarizes the structure and biological function of CHD8, the mechanism of CHD8 gene mutation leading to autism spectrum disorder, and the progress of treatment of autism,indicating that further research on the specific mechanisms by which CHD8 gene mutations lead to problems in neurotransmission and E/I imbalances, as well as the need to combine forces and expertise from different emerging fields, will be key to the advancement of CHD8 function in mental health and disease.

CHD8,autism,E/I imbalance, nervous system development, neurotransmission, therapy