International Journal of Pediatrics Research

Objective To explore the auxiliary diagnostic significance of combined detection of atypical lymphocytes and EB virus antibodies for pediatric IM. Methods This study selected 53 children with infectious mononucleosis who were hospitalized in our hospital between September 2023 and February 2024 as the IM group, and another 60 non infectious mononucleosis fever patients as the non IM group. All patients were tested for atypical lymphocytes and EB virus antibodies (VCA IgM), and statistical analysis was performed. Evaluate the diagnostic value of various detection methods, whether single or combined. Results The proportion of atypical lymphocytes in 53 patients was (16.22 ± 3.47)%, and the positive rate of atypical lymphocytes was 62.26% (33/53). The positive detection rate of VCA IgM antibodies was 83.02% (44/53). Among them, the combination of heterotypic lymphocyte proportion determination and VCA IgM detection has higher sensitivity and accuracy compared to single application. There were significant differences (P<0.05) in the specificity, positive, and negative predictive values between joint testing, individual heterotypic lymphocyte testing, and individual VCA IgM antibody testing. Conclusion The detection of atypical lymphocytes and the combined detection of VCA IgM can serve as auxiliary diagnostic indicators for pediatric IM.

Infectious mononucleosis; Heterotypic lymphocytes; EB virus; Antibody