International Journal of Surgical Research

Objective To observe the control of inflammatory cytokines and clinical efficacy analysis of treatment with disposable negative pressure drainage technique (Vacuum Sealing Draina VSD) in patients with skin defects, bone defects and infections of extremities. Methods Ten patients with skin defects, bone defects and infected wounds of the extremities admitted from January 2021 to October 2021 were randomly grouped into a treatment group and a control group, with 5 cases in each group, to compare the effects of treatment with disposable VSD negative pressure drainage technique, conventional drug exchange treatment followed by reoperation, respectively. Results The inflammatory cytokine control time of 5.0±2.3 days, wound healing time of 18±2.5 days, and functional recovery time of 28±5.5 days for 5 cases treated with disposable VSD negative pressure drainage technique, and the inflammatory cytokine control time of 14.1±3.0 days, wound healing time of 35±4.2 days, and functional recovery time of 53±8.1 days for 5 cases treated with conventional drug exchange. The efficiency of the treatment group was higher than that of the control group (P<0.05) with respect to the time of inflammatory cytokine control, trauma healing, and functional rehabilitation of the trauma cells in both groups. Conclusion Disposable negative pressure VSD drainage technique is more advantageous in both inflammatory cytokine control, trauma healing time, and functional recovery, which helps patients recover as soon as possible and improves their quality of life, and is recommended.

Skin; bone defect and trauma infection; VSD; inflammatory cytokine control; treatment effect