天然产物的生物合成及酶工程研究进展-国际医药研究前沿-CSCIED科技核心评价数据库-手机版

天然产物的生物合成及酶工程研究进展

Progress in biosynthesis and enzyme engineering of natural products

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DOI	10.12208/j.imrf.20240005
刊名	国际医药研究前沿 International Medical Research Frontier
年，卷(期)	2024, 8(1)
作者	谭彩玲,张剑,余伯阳*,
作者单位	中国药科大学江苏南京 ;
摘要	天然产物是动物、植物、微生物来源的特殊代谢产物，为药物研发提供了重要来源。因其绿色、可持续的特点，天然产物的生物合成具有广阔的应用前景，其主要程序包括底盘细胞的确认，代谢途径的设计，发酵工艺的放大。酶作为天然产物生物合成的催化剂，通常不完全具备目标产物合成的所需特性，需对其进行酶工程改造。这些酶工程策略包括定向进化、理性设计、半理性设计，以提升酶特性从而适应于天然产物的生物合成应用。
Abstract	Natural products are special metabolites from animals, plants and microorganisms, which provide an important source for drug research and development. Because of its green and sustainable characteristics, the biosynthesis of natural products has broad application prospects. The main procedures include the identification of chassis cells, the design of metabolic pathways, and the amplification of fermentation processes. As catalysts for natural product biosynthesis, enzymes usually do not have the required properties of target product synthesis, so they need to be modified by enzyme engineering. These enzyme engineering strategies include directed evolution, rational design, and semi-rational design to improve enzyme properties for biosynthetic applications of natural products.
关键词	天然产物；生物合成；酶工程
KeyWord	Natural products; Biosynthesis; Enzyme engineering
基金项目
页码	21-24

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引用本文

谭彩玲,张剑,余伯阳*. 天然产物的生物合成及酶工程研究进展 [J]. 国际医药研究前沿. 2024; 8; (1). 21 - 24.

文献评论

李**昆明医科****** 已认证✔

2025-10-09 03:17:33

这篇题为《天然产物的生物合成及酶工程研究进展》的综述文章系统梳理了天然产物生物合成与酶工程领域的最新研究进展，具有较高的学术价值和实践指导意义。是一篇内容详实、结构严谨的综述，适合作为天然产物合成生物学与酶工程领域的入门与参考材料，对相关领域的研究人员、学生及工业界人士均具有较高的参考价值

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