International Journal of Clinical Research

Objective To investigate the clinical significance of D-dimer and fibrinogen (FIB) levels in patients with different fracture sites. Methods 81 patients with fracture from the Branch Hospital of Huai’an First People’s Hospital from June 2022 to June 2024 were enrolled in this study. The fracture group included 10 patella fractures, 8 femur fractures, 20 rib fractures, 26 thoracic vertebrae fractures, 11 phalanges fractures and 6 phalanges fractures. At the same time, 70 cases of health examination from the Branch Hospital of Huai’an First People’s Hospital were randomly selected as the control group during this period. The values of D-dimer and FIB and the positive detection rate of the two groups were compared. Results The results of D-dimer and FIB in the fracture group were higher than those in the control group (P < 0.05). The levels of D-dimer and FIB of patients with femur fracture, tibia and fibula fracture, vertebra and rib fracture in the fracture group were higher than those in the control group (P < 0.05). In the fracture group, the D-dimer levels, FIB levels and the positive detection rates of D-dimer and FIB were significantly different in different fracture sites. The values of D-dimer and FIB were significantly increased with the severity of the disease(P < 0.05). Conclusion The levels of D-dimer and FIB were significantly different in patients with different fracture sites, and the levels of D-dimer and FIB increased with the progression of the disease. The values of D-dimer and FIB in fracture patients are obviously different from healthy people. The combination of D-dimer and FIB can be used as one of the markers of secondary fibrinolysis for clinical reference.

Fracture; D-dimer; Fibrinogen