International Journal of Clinical Research

Objective: To study the effect of nursing intervention in preventing hemolysis of blood samples caused by venous blood samplers in phase I clinical trials of drugs. Method: 228 subjects who underwent Phase I drug clinical trials in our hospital from June 2021 to June 2023 were randomly divided into an observation group (n=114) and a control group (n=114). The control group subjects received routine nursing intervention, while the observation group subjects received full course nursing intervention from nurses. Result: The SAS and SDS scores of the two groups of subjects before intervention were comparable, with no statistically significant difference (P>0.05); The SAS and SDS scores of the observation group after intervention were lower than those of the control group, and the difference was statistically significant (P<0.05). The incidence of hemolysis in the observation group (7.89%) was significantly lower than that in the control group (23.68%), and the difference was statistically significant (P<0.05). The compliance of subjects in the observation group (90.48%) was significantly higher than that in the control group (71.43%), and the difference was statistically significant (P<0.05). Conclusion: Nursing intervention throughout the entire process can alleviate anxiety and depression among participants in phase I drug clinical trials, reduce the incidence of hemolysis, and significantly improve their compliance.

Nurses full process nursing; Phase I drug clinical trials; Compliance