PD-1在耐多药肺结核患者T淋巴细胞上的表达-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

PD-1在耐多药肺结核患者T淋巴细胞上的表达

Expression of PD-1 on T lymphocytes in patients with multidrug-resistant pulmonary tuberculosis

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DOI	10.12208/j.ijcr.20240344
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2024, 8(9)
作者	巫丽兰,谭守勇*,
作者单位	广东省第二人民医院广东广州 ; 广州市胸科医院广东广州 ;
摘要	分析耐多药肺结核患者自身T淋巴细胞表达和PD-1之间的关系。方法选取对异烟肼、利福平耐药的患者为HR耐药组，对异烟肼、利福平敏感的患者为HR敏感组，健康人群为健康组。采集外周血，运用流式细胞检测技术对其进行T淋巴细胞、CD8+表面PD-1受体的检测。结果分析机体淋巴细胞CD4+表达情况为：HR耐药组与HR敏感组（P=0.016）；HR耐药组以及健康分析组之间的数据比较，对应p<0.05；且HR敏感组以及健康分析组之间的数据比较，对应p<0.05。针对机体淋巴细胞CD8+表达情况为：HR耐药组与HR敏感组（P=0.012）；HR耐药组与健康分析组（P<0.001）；HR敏感组与健康分析组（P=0.001）。结论 HR耐药相关的肺结核检验中，T淋巴细胞CD4+、和T淋巴细胞CD8对应的PD-1受体均较HR敏感类型患者、健康群体的受体水平高。
Abstract	Objective: To analyze the relationship between self T lymphocyte expression and PD-1 in multidrug-resistant pulmonary TB patients. Methods: Patients resistant to isoniazid and rifampin were selected as the HR resistant group, patients sensitive to isoniazid and rifampin were selected as the HR sensitive group, and the healthy population was the healthy group. Peripheral blood was collected and tested for T lymphocytes and CD8 + PD-1 surface receptor by flow cytometry technology. Results: CD4 + expression of lymphocytes was: HR resistant and HR sensitive groups (P=0.016); data comparison between HR resistant and healthy analysis groups, corresponding to p <0.05; and data comparison between HR sensitive and healthy analysis groups, corresponding p <0.05. CD8 + expression of lymphocytes of the body was: HR resistant and HR sensitive group (P=0.012); HR resistant and healthy analysis group (P <0.001); and HR sensitive group and health analysis group (P=0.001). Conclusion: In the pulmonary tuberculosis test of HR resistance, PD-1 receptors corresponding to CD4 + of T lymphocytes and CD8 were higher than those of HR sensitive patients and healthy groups.
关键词	耐多药肺结核；淋巴细胞亚群；PD-1受体
KeyWord	Multidrug-resistant tuberculosis, Lymphocyte subsets, PD-1 Receptor
基金项目
页码	25-30

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巫丽兰,谭守勇*. PD-1在耐多药肺结核患者T淋巴细胞上的表达 [J]. 国际临床研究杂志. 2024; 8; (9). 25 - 30.

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