International Journal of Medicine and Data

Objective To explore the effect of combined drug therapy (levofloxacin + metronidazole) on postoperative infection in patients with acute appendicitis. Methods Sixty patients with acute appendicitis admitted to our hospital from April 2023 to April 2024 (all with postoperative infection complications) were selected and divided into experimental group (30 cases with levofloxacin plus metronidazole) and control group (30 cases with metronidazole alone) according to random sampling method. The inflammatory indicators (CRP/ C-reactive protein, WBC/ white blood cell count), the time of fever reduction, wound healing, postoperative hospitalization, and the occurrence of adverse reactions (nausea, vomiting, vertigo) during treatment were compared between the two groups before and after treatment for 3 days. Results There was no significant difference between the two groups before treatment and the incidence of adverse reactions during treatment (P > 0.05). After 3 days of treatment, CRP and WBC indexes in the experimental group were lower than those in the control group, and fever reduction, wound healing and postoperative hospital stay in the experimental group were shorter than those in the control group (P < 0.05). Conclusion The combined therapy of levofloxacin and metronidazole in the treatment of postoperative infection in patients with acute appendicitis has a significant clinical effect, which is better than metronidazole alone, and the safety is guaranteed.

Levofloxacin; Metronidazole; Acute appendicitis; Postoperative infection; Combination therapy