International Journal of Clinical Research

Objective To evaluate the efficacy and safety of Pudilan Xiaoyan oral liquid in the adjuvant treatment of Helicobacter pylori (Hp) infection. Methods SinoMed, CNKI, Wanfang, VIP, PubMed, Embase and the Cochrane library were searched by computer to collect the randomized controlled trial (RCT) of Pudilan Xiaoyan oral liquid combined with conventional eradication therapy for Hp infection. The search period was from the establishment of the database to March 2024. Two researchers were selected according to inclusion and exclusion criteria for literature screening and data extraction, and the risk of bias was evaluated for included studies. RevMan 5.3 software was used for meta-analysis, and TSA 0.9 software was used for sequential analysis of Hp eradication rate. Results A total of 10 RCTS were included, with a total of 1110 patients (557 patients in test group and 553 patients in control group). The results of meta-analysis showed as follows: ①Hp eradication rate: Compared with conventional eradication therapy, Pudi LAN Xiaoyan oral liquid combined with conventional therapy could improve Hp eradication rate [RR=1.21, 95%CI (1.13,1.29), P <0.00001]; ② Incidence of total adverse reactions: Although the incidence of total adverse reactions of Pudilan Xiaoyan oral liquid combined with conventional eradication therapy was lower than that of control group, the difference was not statistically significant [RR=0.86, 95%CI(0.64, 1.16), P =0.15]. The results of sequential analysis suggest that the evidence is reliable. Conclusion Compared with conventional eradication therapy, Pudilan Xiaoyan oral liquid combined with conventional eradication therapy can improve the eradication rate of Hp, and does not increase the incidence of adverse reactions. Subject to the quality and quantity of included studies, these conclusions need to be confirmed by multicenter, high-quality RCTS.

Pudilan anti-inflammatory oral liquid; Helicobacter pylori; Meta-analysis; Sequential analysis of experiments