脉管复康片对ASCVD患者动脉硬化程度、血脂、炎症因子的影响-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

脉管复康片对ASCVD患者动脉硬化程度、血脂、炎症因子的影响

Effects of Maiguanfukang tablets on the degree of arteriosclerosis, blood lipids and inflammatory factorsin patients with ASCVD

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DOI	10.12208/j.ijcr.20240024
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2024, 8(1)
作者	谢福军*,冯连云,马红梅,孙健,顾君昌,张振华,薛春祥,常艳微,
作者单位	天津市河东区中山门医院天津 ; 天津市东丽区华明镇社区卫生服务中心天津 ; 天津市东丽区金桥街社区卫生服务中心天津 ; 天津市河东区二号桥街社区卫生服务中心天津 ; 天津市河东区富民路街社区卫生服务中心天津 ; 天津市河东区常州道街社区卫生服务中心天津 ;
摘要	探讨脉管复康片对动脉粥样硬化性心血管疾病（ASCVD）患者血脂、动脉粥样硬化程度、炎症因子的影响。方法选取6个中心82例ASCVD患者，按照随机数字表法分为试验组39例和对照组43例，对照组予阿司匹林肠溶片抗小板、阿托伐他汀钙片调脂的标准治疗，试验组在此基础上联合脉管复康片治疗，观察周期均为48周，比较两组患者治疗前后血清甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白-C（LDL-C）、高密度脂蛋白-C（HDL-C）、颈动脉内膜中层厚度（IMT）、颈动脉斑块（Crouse）评分变化以及炎症因子血清超敏C反应蛋白（hs-CRP ）、单核细胞趋化蛋白-1（MCP-1）、巨噬细胞移动抑制因子（MIF）、肿瘤坏死因子-ɑ（TNF-ɑ）、细胞黏附分子-1（VCAM-1）、基质金属蛋白酶-9（MMP-9）、白细胞介素-1β（IL-1β）水平变化。结果治疗后试验组IMT及Crouse评分均显著低于治疗前（P＜0.01）；TG、TC、LDL-C、HDL-C两组比较无明显差异；hs-CRP、MCP-1、MIF、TNF-ɑ、VCAM-1、MMP-9、IL-1β水平均较治疗前下降，且治疗后试验组患者各指标水平均明显低于对照组（P＜0.01）。结论脉管复康片可显著抑制ASCVD患者炎症因子表达，保护血管内皮细胞及稳定、延缓粥样硬化斑块发生、发展。
Abstract	Objective To investigate the effects of Maiguanfukang tablet on blood lipid, atherosclerosis degree and inflammatory factors in patients with atherosclerotic cardiovascular disease (ASCVD). Methods A total of 82 patients with ASCVD from 6 centers were selected and divided into experimental group (39 cases) and control group (43 cases) according to random number table method. The control group received standard treatment of aspirin enteric-coated tablets and atorvastatin calcium tablets for lipid regulation, and the experimental group received combined treatment with Maiguangfukang tablets on this basis. The observation period was 48 weeks. Serum triglyceride (TG), cholesterol (TC), low density lipoprotein C (LDL-C), high density lipoprotein C (HDL-C), carotid intimax-media thickness (IMT), carotid plaque (Crouse) score and the inflammatory factor serum hypersensitive C-reactive protein (hs-CRP) were compared between the two groups before and after treatment ), monocyte chemoattractant protein-1 (MCP-1), macrophage migration inhibitor factor (MIF), tumor necrosis factor-alpha (TNF-alpha), cell adhesion molecule-1 (VCAM-1), matrix metalloproteinase-9 (MMP-9), interleukin-1β (IL-1β) levels changed. Results IMT and Crouse scores were significantly lower after treatment than before treatment (P < 0.01). There was no significant difference between TG, TC, LDL-C and HDL-C groups. The levels of hs-CRP, MCP-1, MIF, TNF-alpha, VCAM-1, MMP-9 and IL-1β were all decreased compared with those before treatment, and the levels of all indexes in experimental group were significantly lower than those in control group after treatment (P < 0.01). Conclusion Maaiguanfukang tablet can significantly inhibit the expression of inflammatory factors in ASCVD patients, protect vascular endothelial cells, stabilize and delay the occurrence and development of atherosclerotic plaques.
关键词	脉管复康片；ASCVD；IMT；Crouse评分；炎症因子
KeyWord	Mai Guan Fukang tablet; ASCVD; IMT; Crouse score; Inflammatory factor
基金项目
页码	91-96

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引用本文

谢福军*,冯连云,马红梅,孙健,顾君昌,张振华,薛春祥,常艳微. 脉管复康片对ASCVD患者动脉硬化程度、血脂、炎症因子的影响 [J]. 国际临床研究杂志. 2024; 8; (1). 91 - 96.

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