International Journal of Clinical Research

Objective To explore the effect of low-dose spironolactone in elderly patients with refractory hypertension. Methods 48 elderly patients with refractory hypertension admitted from April 2022 to April 2023 were selected as the study subjects. They were randomly divided into a control group (n=24 cases, receiving conventional treatment) and an experimental group (n=24 cases, receiving low-dose spironolactone treatment) using a random number table method. Compare blood pressure levels and quality of life between two groups. Results The systolic and diastolic blood pressure in the experimental group significantly decreased, both lower than those in the control group, and the difference was statistically significant (P<0.05); The quality of life in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Low dose spironolactone can effectively reduce blood pressure and improve quality of life in elderly patients with refractory hypertension, and has promotional value.

Low dose spironolactone; Elderly people; Refractory hypertension; Effect evaluation