International Journal of Clinical Research

Asthma is a very heterogeneous inflammatory disease, mainly due to inflammatory cells and their triggering cellular factors, the disease will cause long-term airway inflammation. Asthma in the bronchial frequency is higher, the disease is usually accompanied by airway inflammation. Most of the asthma patients can not be effectively treated, and eventually will evolve into severe asthma. The significant symptoms of the disease include airway remodeling and airway reverse obstruction, the disease is mostly produced by inhaled allergenic substances, and will lead to a series of asthma-related symptoms, such as respiratory distress, cough, wheezing, and wheezing caused by airway contraction, resulting in asthma wheeze. In the in-depth study of the formation principle of asthma, immune imbalance and its corresponding academic research plays a key role. This article will review the latest research results on how methyl CpG binding protein 2 (MBD2) and cytokine signaling inhibitor 3 (SOCS3) affect helper T cell 17 (Th17) cells for severe asthma.

Helper T cell 17; Methyl CpG binding protein 2; Cytokine signaling inhibitor 3; Severe asthma