International Journal of Clinical Research

Objective To investigate the effect of ECMO (extracorporeal membrane oxygenation) on severe ARDS patients (acute respiratory distress syndrome). Methods 92 patients with severe acute respiratory distress syndrome treated in our hospital from October 2022 to December 2023 were selected for medical practice, and randomly divided into two groups: drug treatment group (ulinastatin, cilvelestat sodium) with general treatment, and special treatment group treated with ECMO. The hemodynamic index and oxygenation index of the two groups were analyzed. Results After intervention, the hemodynamic indexes of the special treatment group were better than those of the drug treatment group, p<0.05; Before intervention, the data of oxygenation index between the two groups were compared (p>0.05). The mean oxygenation index of patients in special treatment group was (195.26±12.43) mmHg in one day after intervention, (293.65±20.35) mmHg in two days after intervention, and (380.75±31.46) mmHg in one week after intervention, which were all higher than those in drug treatment group, p<0.05. There were 2 cases of pruritus and 2 cases of nausea and vomiting in the special treatment group (8.7%), which was lower than 10.9% in the drug treatment group (p<0.05). Conclusion The introduction of ECMO technology in the treatment of severe ARDS has achieved remarkable therapeutic effect and can be extended.

ECMO; Severe ARDS; Hemodynamics; Application effect