代谢组学在发掘不同中医证型缺血性脑卒中生物标志物的应用与进展-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

代谢组学在发掘不同中医证型缺血性脑卒中生物标志物的应用与进展

Application and progress of metabolomics in discovering biomarkers of ischemic strokein different TCM syndromes

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DOI	10.12208/j.ijcr.20240158
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2024, 8(5)
作者	张栋林,余伯阳*,
作者单位	中国药科大学江苏南京 ;
摘要	缺血性脑卒中，也称脑梗死。是由于各种病因引发的大脑血液供应不足而造成脑组织缺氧性坏死的一种严重疾病。作为脑血管疾病中的一大类，缺血性脑卒中在全球范围内都是主要的健康威胁。中医证型是中医对疾病在发展过程中病理状态所做的概况，是中医诊断与治疗的关键与基础。代谢组学，作为系统生物学的一个重要分支，主要研究生物体内所有代谢物的变化。代谢物，是生物体内生化反应的产物或底物，直接反映了细胞的生命活动状态。中医素有“内病外显”之说，意味着疾病的外在证型必然有其内在的病理基础。本文从代谢组学为基础，探讨了代谢组学针对不同中医证型的缺血性脑卒中的生物标志物的发掘的进展。
Abstract	Ischemic stroke, also known as cerebral infarction. It is a serious disease of hypoxic necrosis of brain tissue caused by insufficient blood supply to the brain caused by various causes. As a major category of cerebrovascular diseases, ischemic stroke is a major health threat worldwide. TCM syndrome type is the general situation of the pathological state of the disease in the process of development, which is the key and basis of TCM diagnosis and treatment. Metabolomics, as an important branch of systems biology, mainly studies the changes of all metabolites in living organisms. Metabolites are the products or substrates of biochemical reactions in organisms, which directly reflect the life activity state of cells. Traditional Chinese medicine is known as the "internal disease outward appearance", which means that the external syndromes of diseases must have their internal pathological basis. Based on metabolomics, this paper discusses the development of biomarkers for ischemic stroke in different TCM syndromes.
关键词	缺血性脑卒中；代谢组学；中医证型；生物标志物
KeyWord	Ischemic stroke; Metabolomics; TCM syndrome type; Biomarker
基金项目
页码	1-3

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引用本文

张栋林,余伯阳*. 代谢组学在发掘不同中医证型缺血性脑卒中生物标志物的应用与进展 [J]. 国际临床研究杂志. 2024; 8; (5). 1 - 3.

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