International Journal of Clinical Research

Objective To observe the efficacy and safety of 5-aminoketone valerate photodynamic (5-ALA-PDT) combined with intense pulse light in the treatment of moderate and severe acne, to explore the effective clinical treatment of acne and the prevention of scar formation. Methods 60 patients with moderate and severe acne were divided into test group and control group. The test group was treated with 5-aminovalerate combined with intense pulse light, and the control group was treated with 5-aminoone valerate photodynamic once every 4 weeks for 3 consecutive times. Observe observation in week 2, week 4 and week 6 respectively, and timely follow up and correct adverse reactions. Results In the test and control groups, the recovery rate and response rate of acne patients at weeks 4 and 6 decreased (P <0.05); the 3-month follow-up response rate was 96%, and the ECCA and DLQI scores were significantly decreased after treatment (P <0.05). The patient experienced mild intraoperative pain, postoperative erythema, dry tension and edema, and subsided from 3 to 12 d after symptomatic treatment. Conclusion Treatment with moderate and severe acne has remarkable effect, high patient satisfaction and good safety, which is worthy of clinical promotion and application.

Photodynamic; 5-aminoone valeric acid; Strong pulse light; Moderate and severe acne