Journal of International Psychiatry

【Abstract】Objective To explore the adverse reactions of COVID-19 vaccine in patients with severe mental disorders. Methods A total of 412 severe mental disorders cases who get vaccinated against COVID-19 were selected from the home management patients in the national severe mental disorder management system from May 1, 2021 to May 25, 2021, in Chongqing Jiangbei District and Wanzhou District. Adverse event response rating scale issued by the China State Food and Drug Administration and PANSS positive symptom scale was used to evaluate the adverse reactions and positive symptoms within one week after inoculation of COVID-19. Results The incidence of serious adverse events in patients with severe mental disorders was 0, the incidence of general adverse reactions was 9.5%, the incidence of positive symptoms within one week was 3.2%, and there was a correlation between adverse reactions and positive symptoms (=0.131, P=0.008). Logistic regression analysis showed that adverse reactions (OR=4.68) is a high risk factor for the occurrence of positive symptoms. Conclusions The incidence of adverse reactions to COVID-19 vaccine in patients with severe mental disorders is low, and the safety is high. Adverse events is a high risk factor for positive symptoms.

severe mental disorders; COVID-19; vaccine