亚麻醉剂量艾司氯胺酮对乳腺癌术后早期康复与负性情绪的影响
Effect of Linen Intoxication Dose Esketamine on Early Recovery and Negative Emotion after Breast Cancer Surgery
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2023, 50(2) |
| 作者 |
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| 作者单位 |
河南大学第一附属医院麻醉科 ;
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| 摘要 |
摘要 目的：探讨亚麻醉剂量艾司氯胺酮对乳腺癌术后早期康复与负性情绪的影响。方法：选择2020年1月-2022年3月86例乳腺癌患者为研究对象，采用根治手术治疗，数字表法随机分为对照组与观察组，对照组采用常规麻醉，观察组在此基础上术前给予0.2 mg/kg的亚麻醉剂量艾司氯胺酮。评价术前、术后1d、3d焦虑自评量表（SAS）、抑郁自评量表（SDS），比较两组患者喉罩拔除时间、清醒时间、镇痛泵按压次数以及术后早期认知功能障碍、谵妄、恶心呕吐等并发症发生率。结果：观察组术后1d、3dSDS评分、SAS评分显著低于术前，且显著低于对照组，（P<0.05），对照组术后1d、3dSDS评分、SAS评分显著高于术前，（P<0.05）；观察组喉罩拔除时间、清醒时间、镇痛泵按压次数显著低于对照组，（P<0.05）；两组认知功能障碍、谵妄、恶心呕吐发生率差异无统计学意义(P>0.05)。结论：亚麻醉剂量艾司氯胺酮能够提升乳腺癌术后早期康复质量，减轻术后早期焦虑、抑郁情绪，且用药安全有效。
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| Abstract |
[Abstract] Objective To explore the effect of linen intoxication dose of Esketamine on early rehabilitation and negative emotion after breast cancer surgery. Methods Eighty-six patients with breast cancer from January 2020 to March 2022 were selected as the study subjects. The patients were randomly divided into the control group and the observation group by the number table method. The control group was given routine anesthesia, and the observation group was given 0.2 mg/kg of ketamine before operation. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were evaluated before operation, 1 day and 3 days after operation. The time of LMA removal, awake time, times of pressing analgesia pump and the incidence of early postoperative cognitive dysfunction, delirium, nausea and vomiting were compared between the two groups. Results The SDS scores and SAS scores of the observation group were significantly lower than those of the control group 1 day and 3 days after operation (P<0.05). The SDS scores and SAS scores in the control group were significantly higher 1 day and 3 days after operation than those before operation (P<0.05). The time of LMA removal, awake time and the times of pressing analgesia pump in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the incidence of cognitive dysfunction, delirium, nausea and vomiting between the two groups (P>0.05). Conclusion Linen intoxication dose of Esketamine can improve the quality of early rehabilitation after breast cancer surgery, reduce early postoperative anxiety and depression, and is safe and effective.
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| 关键词 |
关键词：亚麻醉剂量;艾司氯胺酮;乳腺癌;早期康复;负性情绪
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| KeyWord |
Key words Linen intoxication dose; Esketamine; Breast cancer; Early rehabilitation; Negative emotion
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| 基金项目 |
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| 页码 |
322-324 |
许远征*.
亚麻醉剂量艾司氯胺酮对乳腺癌术后早期康复与负性情绪的影响 [J].
国际精神病学杂志.
2023; 50; (2).
322 - 324.