Journal of International Psychiatry

[Abstract] Objective To investigate the effects of sevoflurane and propofol on cognitive function and negative emotions after breast cancer surgery in elderly patients. Methods A total of 100 elderly breast cancer patients in our hospital from April 2019 to April 2022 were the subjects of this study, and all of whom underwent radical breast cancer surgery. They randomly divided into the two groups, namely sevoflurane group and propofol group. Intraoperative anesthesia was maintained by continuous inhalation of sevoflurane and target-controlled infusion of propofol, respectively. The two groups were compared before and after operation with Brief Mental State Scale (MMSE), Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS). Postoperative agitation, cognitive dysfunction and other complications were recorded. Results The postoperative MMSE scores in both groups were significantly lower than those before surgery, and the postoperative propofol group was significantly higher than that in the sevoflurane group (P<0.05). The postoperative SAS and SDS scores of the two groups were significantly higher than those before surgery, and the postoperative propofol group was significantly lower than that of the sevoflurane group (P<0.05). The incidences of postoperative cognitive dysfunction and delirium in the propofol group were significantly lower than those in the sevoflurane group (P<0.05). There was no significant difference in the incidence of agitation (P>0.05). Conclusion When sevoflurane and propofol are used in elderly breast cancer surgery, the postoperative cognitive impairment and negative emotions after propofol are less severe, which can reduce the incidence of complications such as restlessness and cognitive dysfunction.

Key words Sevoflurane; Propofol; Elderly; Breast Cancer; Surgery; Cognitive Function; Negative Emotions