肠道菌群与抑郁障碍关联性的研究进展

Research progress on the association between gut microbiota and depressive disorder

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2023, 50(4)
作者
作者单位

新疆医科大学 ;
新疆医科大学第一附属医院临床医学研究院 ;
新疆医科大学第一附属医院 ;

摘要
抑郁是常见的心理健康问题,其中有一部分是严重精神疾病——重度抑郁障碍(Major depressive disorder,MDD),MDD患病率、致残率及致死率高,造成的社会负担重。然而,MDD的病因和发病机制至今尚不十分清晰,目前认为与遗传和环境、神经发育异常以及神经生化等因素有关。近年来,众多学者发现MDD患者肠道菌群(Gut microbiota,GM)的变化与其疾病存在显著的相关性,并提出微生物-肠-脑轴的概念以解释GM对MDD的影响。本文就GM与MDD之间的相关研究新进展予以文献复习。
Abstract
Depression is a common mental health problem, of which Major depressive disorder (MDD) , which has a high morbidity, disability and mortality rate and is a major social burden.However, the etiology and pathogenesis of MDD are still unclear. Currently, it is believed to be related to genetic and environmental factors, neurodevelopmental abnormalities, and neurobiochemical factors.In recent years, many scholars have found that the changes of gut microbiota (GM) in MDD patients are significantly correlated with their diseases, and proposed the concept of microbe-gut-brain axis to explain the effect of GM on MDD.This paper reviews the literature on the relationship between GM and MDD.
关键词
抑郁障碍;肠道菌群;微生物-肠-脑轴
KeyWord
depression disorder;gut microbiota;Microbiome-gut-brain axis
基金项目
页码 592-595
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毛俊雄,马琦,张丽丽,罗晓,彭朕磊,伊琦忠*. 肠道菌群与抑郁障碍关联性的研究进展 [J]. 国际精神病学杂志. 2023; 50; (4). 592 - 595.

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