Journal of International Psychiatry

As the mental illness with the highest proportion of global burden, depression has received more and more attention. At present, the research on antidepressant treatment mainly focuses on the classical monoaminergic nervous system. However, more and more studies have shown that the glutamatergic nervous system has become a hot spot in the research on the pathophysiology of depression.Therefore, this article reviews the neurobiological mechanism and research progress of glutamatergic system in the treatment of depression.

glutamatergic nervous system;antidepressant therapy