Journal of International Psychiatry

【Abstract】Objective：To explore the changes and influencing factors of inflammatory factors in children and adolescents with depression and suicidal tendency.Methods：Retrospective analysis was made on the clinical data of 150 cases of adolescent depression admitted to our hospital from January 2021 to September 2022. According to the Beck Suicide Intention Scale (BSI-CV) score, 150 patients were divided into the suicide prone group (group A, 87 cases) and the non suicide prone group (group B, 63 cases). In addition, 80 adolescents who had undergone physical examination in our hospital at the same time were selected as the healthy control group.Compare the serum inflammatory factors [interleukin-6 (IL-6), CC chemokine ligand 2 (CCL2) and tumor necrosis factor in different groups of patients α （tumor necrosis factor- α， TNF- α）、 Interleukin-1 β （interleukin-1 β， IL-1 β）] Horizontal.Result：(1) Group A IL-6, CCL2, TNF- α、 IL-1 β The levels of IL-6, CCL2 and TNF in group B were higher than those in group B and healthy control group- α、 IL-1 β The level was significantly higher than that of the healthy control group (P<0.05); (2) The results of multiple logistic regression analysis showed that the course of depression, family history of psychosis, recent relationship with parents, and IL-1 β Both BSI-CV and BSI-CV were independent risk factors for suicidal tendency in patients with depression (P<0.05).Conclusion:Children and adolescents with depression accompanied by suicidal tendency showed an increase in serum inflammatory factors, a long course of depression, a family history of psychosis, a poor relationship with parents in the near future, and IL-1 β High level and rising BSI-CV score are risk factors leading to suicidal tendency in adolescent depression, which should be paid attention to clinically.

【Key words】Children; Adolescent depression; Suicidal tendency; Inflammatory factors; influence factor