盐酸度洛西汀对晚期癌性疼痛患者疼痛程度、不良心理状态及单胺神经递质水平的影响
Effects of Duloxetine hydrochloride on pain degree, adverse mental state and monoamine neurotransmitter levels in patients with advanced cancer pain
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2023, 50(4) |
| 作者 |
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| 作者单位 |
陕西省宝鸡市中心医院 ;
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| 摘要 |
摘要 目的：分析晚期癌性疼痛患者应用盐酸度洛西汀对疼痛程度、不良心理状态及单胺神经递质水平的影响。方法：将2020年10月至2022年10月期间我院收治的86例晚期癌性疼痛患者作为研究对象，采用随机数字表法进行分组。对照组43例给予盐酸羟考酮治疗，实验组43例在此基础上增加盐酸度洛西汀治疗。4周后，对比两组患者疼痛程度、不良心理状态、单胺神经递质水平、不良反应。结果：实验组患者疼痛视觉模拟量表（VAS）评分、简明疼痛评估量表（BPI）评分分值均低于对照组（P＜0.05）；实验组患者汉密尔顿抑郁量表（HAMD）评分、汉密尔顿焦虑量表（HAMA）评分分值均低于对照组（P＜0.05）；实验组患者去甲肾上腺素（NE）、5-羟色胺（5-HT）、多巴胺（DA）水平均高于对照组（P＜0.05）；两组患者不良反应发生率比较（P＞0.05）。结论：盐酸度洛西汀能够有效减轻晚期癌性疼痛患者疼痛程度，改善不良心理状态及单胺神经递质水平，且安全性高。
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| Abstract |
Abstract Objective: To analyze the effects of duloxetine hydrochloride on pain degree, adverse mental state and monoamine neurotransmitter level in patients with advanced cancer pain. Methods: A total of 86 patients with advanced cancer pain admitted to our hospital from October 2020 to October 2022 were selected as research objects and grouped by random number table method. Forty-three patients in the control group were treated with oxycodone hydrochloride, and 43 patients in the experimental group were treated with duloxetine hydrochloride. After 4 weeks, pain degree, adverse psychological state, monoamine neurotransmitter level and adverse reactions were compared between the two groups. Results: The scores of visual Analog Scale (VAS) and Concise Pain Assessment Scale (BPI) in experimental group were lower than those in control group (P < 0.05). The scores of Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) in the experimental group were lower than those in the control group (P < 0.05). The levels of norepinephrine (NE), 5-hydroxytryptamine (5-HT) and dopamine (DA) in experimental group were higher than those in control group (P < 0.05); The incidence of adverse reactions was compared between 2 groups (P > 0.05). Conclusion: Duloxetine hydrochloride can effectively reduce the pain degree of patients with advanced cancer pain, improve the adverse mental state and the level of monoamine neurotransmitter, with high safety.
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| 关键词 |
关键词：盐酸度洛西汀；晚期癌性疼痛；疼痛程度；不良心理状态；单胺神经递质
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| KeyWord |
Key words: Duloxetine hydrochloride; Advanced cancer pain; The degree of pain; Bad mental state; Monoamine neurotransmitter
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| 基金项目 |
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| 页码 |
827-829 |
闫晓红*.
盐酸度洛西汀对晚期癌性疼痛患者疼痛程度、不良心理状态及单胺神经递质水平的影响 [J].
国际精神病学杂志.
2023; 50; (4).
827 - 829.