Journal of International Psychiatry

Schizophrenia is a group of unknown etiology of severe mental disorders, with cognitive, thinking, emotion, behavior and other aspects of mental activity abnormalities, accompanied by obvious occupational and social function damage. Basic and clinical research on schizophrenia has been an important topic in psychiatry. The research on the correlation between microRNA and schizophrenia has become one of the hot topics in recent years. MicroRNA is one of the types of non-coding RNAs that exist in cells. MicroRNA has been widely paid attention to by the scientific community due to regulating gene expression and affecting cell life activities. Studies have shown that MicroRNA, as an important post-transcriptional regulator, is closely related to schizophrenia. This article reviews the recent advances in microRNA and schizophrenia in pathological mechanism, symptomatology, treatment and prognosis.

schizophrenia；microRNA；pathological mechanism；diagnosis and treatment