| Abstract |
[Abstract] Objective: To systematically analyze the efficacy and psychological impact of sequential treatment with butylphthalide in patients with acute cerebral infarction and cognitive impairment. Method: A total of 160 patients with acute cerebral infarction combined with cognitive impairment who underwent treatment in our hospital from September 2020 to September 2022 were selected as the study subjects. Based on "different treatment methods", they were equally divided into a control group and an observation group, with 80 patients in each group receiving income. The control group received intravenous drip therapy with butylphthalide, while the observation group received sequential treatment with butylphthalide. The clinical efficacy, daily living ability (Barthel) score, and Neurological Impairment Scale (NIHSS) score, Minimal Mental State Scale (MMSE) score, psychological state score, and incidence of drug side effects. Result: Before treatment, there was no statistically significant difference in Barthel index, NIHSS score, MMSE score, and psychological state score between the two groups of patients, P>0.05; After treatment, compared with the control group, the Barthel index and MMSE score of the observation group patients were significantly higher, while the NIHSS score and psychological state score were significantly lower, P<0.05; After treatment, compared to the control group, the clinical efficacy of the observation group patients was significantly higher, P<0.05; After treatment, compared to the control group, the incidence of drug side effects in the observation group was slightly lower, with data comparison P>0.05 (no statistically significant difference). Conclusion: The implementation of sequential treatment with butylphthalide in patients with acute cerebral infarction and cognitive impairment can actively improve its therapeutic effect, improve neurological deficits and cognitive function, stabilize psychological status, improve drug safety, and provide a good new approach for clinical treatment.
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