| Abstract |
【Abstract】Objective Explore the correlation between serum folate, VB12, and homocysteine levels and cognitive function in patients with schizophrenia..Methods 101 patients with schizophrenia admitted to the Shanghai Civil Affairs X Mental Health Center and 51 healthy controls were selected to determine the correlation between folic acid, VB12, Hcy, and cognitive function in patients with schizophrenia during the same period..Results There was no significant difference between the study group and the control group in age, education level, prevalence of hypertension or diabetes and education level (P>0.05); There were statistically significant differences in immediate memory, visual span, speech function, attention, delayed memory, total RBANS score, VB12, Hcy levels, and folate levels among the study group patients (P<0.05); The levels of VB12 and folic acid in the study group were lower than those in the control group, and there was a statistically significant difference in Hcy levels compared to the control group (P<0.05); The study group showed a negative correlation between folic acid levels and negative symptoms, a negative correlation between VB12 levels and patient age and course of disease, a positive correlation between positive symptoms, and a negative correlation between Hcy levels and visual span, folic acid, and VB12. Conclusion The elevated serum HCY and low serum VB12 levels in male patients with chronic schizophrenia are correlated with cognitive function.
|