| Abstract |
【Abstract】Objective To investigate the associations between nonsuicidal self-injury (NSSI) with clinical symptoms and cognitive function in patients with major depressive disorder (MDD) and bipolar disorder (BD). Methods A total of 242 subjects were enrolled in this study, including 55 MDD patients, 66 BD Ⅰ patients, 59 BD Ⅱ patients, and 62 healthy controls. NSSI behavior score, current emotional and psychiatric symptom severity score, neurological/social cognitive function score were assessed to explore the association between emotional and psychiatric symptoms and NSSI behavior. Results In MDD group, cognitive function and clinical symptoms had no significant effect on NSSI (Ps>0.05). In BD Ⅰ patients, a score on the Trail Making Test (P=0.033, β=0.044), as well as the severity depressive symptoms (P=0.002, β=-0.104), anxiety symptoms (P=0.004, β=-0.099), mania symptoms (P=0.011, β=-0.064) had a significant effect on the occurrence of NSSI behavior, while maze score had a marginal significant effect on the occurrence of NSSI behavior (P=0.065, β= -0.09). In BD Ⅱ patients, the severity of depressive symptoms (P=0.014, β=-0.111) and psychotic symptoms (P=0.002, β=-0.101) had significant effects on the occurrence of NSSI behavior, and the impairment of emotional management ability had marginal significant effects on the occurrence of NSSI behavior (P=0.092). Conclusions Compared with MDD, self-harm in BD patients was more closely associated with current mood symptoms, psychiatric symptoms, and cognitive function. In each cognitive dimension, neurocognition may affect the occurrence of self-harm behavior in BD Ⅰ patients; Social cognition may affect the occurrence of self-harm behavior in BD Ⅱ patients.
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