Journal of International Psychiatry

[Abstract] Objective To explore the status quo of depression and anxiety in patients with functional dyspepsia (FD) and its impact on clinical symptoms and quality of life. Methods Eighty-eight FD patients from August 2020 to October 2022 were selected as the study subjects. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess the anxiety and depression status of patients. The patients with anxiety or depression were set as the observation group, and the other patients were set as the control group. The score of dyspepsia symptoms, functional dyspepsia quality of life scale (FDDQL) and serum gastrin (GAS) and motilin (MLT) levels between the two groups were compared. The correlation between SAS score, SDS score and the above indicators in the observation group were analyzed. Results Eighty-eight FD patients were complicated with anxiety in 24 cases and depression in 20 cases, of which 17 were comorbid. The score of dyspepsia symptoms in the observation group was significantly higher than that in the control group, and the score of FDDQL was significantly lower than that in the control group (P<0.05). The level of serum GAS in the observation group was higher than that in the control group, and the level of MLT was lower than that in the control group (P<0.05). SAS score and SDS score of patients in the observation group were positively correlated with dyspepsia symptom score and GAS level, and negatively correlated with FDDQL score and MLT level (P<0.05). Conclusion The detection rate of anxiety and depression in FD patients is high, and the combination of anxiety and depression may aggravate the symptoms of dyspepsia, reduce the quality of life, and affect the level of gastrointestinal hormones.

Key words Functional Dyspepsia; Depression; Anxiety; Clinical Symptoms; Quality of Life; Gastrointestinal Hormone