Journal of International Psychiatry

[Abstract] Objective To investigate the magnetic resonance (MRI) characteristics of brain atrophy in patients with subcortical vascular cognitive dysfunction (SIVD-CI). Methods The study was observed in 76 patients with subcortical ischemic vascular disease (SIVD) from January 2020 to June 2022. The Simple Mental State of Intelligence Scale (MMSE) was assessed and set up as SIVD-CI group (41 patients) as well as control group (35 patients). 3.0T cranial MRI scan was performed. The visual grade score was used to evaluate frontal, temporal and parietal atrophy and cerebral white matter sparing. The correlation between the MMSE scores and the patients in the SIVD-CI group was also analyzed. Results The frontal, temporal, parietal and total cerebral atrophy scores were significantly higher in the SIVD-CI group than in the control group (P<0.05). the frontal, temporal, parietal and total cerebral white matter atrophy scores were significantly higher in the SIVD-CI group than in the control group (P<0.05). the MMSE scores were negatively correlated with the total cerebral atrophy and total cerebral white matter atrophy scores in the SIVD-CI group (P<0.05). Conclusion MRI of patients with SIVD-CI suggests the presence of brain atrophy in the frontal, temporal, and parietal regions as well as cerebral white matter sparing, which should be given clinical attention.

Key words Subcortical Ischemic Vascular Disease; Cognitive Dysfunction; Brain Atrophy; Magnetic Resonance