产后抑郁与甲状腺激素水平的关系研究

Study on the Relationship Between Postpartum Depression and Thyroid Hormone Levels

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2023, 50(5)
作者
作者单位

濮阳市妇幼保健院 医学检验科 ;

摘要
【摘要】探讨产后抑郁(PPD)与甲状腺激素水平的关系。方法 本研究选择2020年4月-2022年8月100 产妇为研究对象,采用爱丁堡产后抑郁量表 (EPDS)进行抑郁评估,根据是否合并PPD设为PPD组以及对照组,比较两组产妇一般资料,检测两组促甲状腺激素 (TSH)、游离三碘甲状腺原氨酸 (FT3)、三碘甲状腺原氨酸 (T3)、四碘甲状腺原氨酸 (T4)游离甲状腺素 (FT4)等甲状腺功能指标,分析PPD患者甲状腺功能指标与EPDS评分的相关性。结果 100 产妇中34例并发PPD,PPD组与对照组年龄、受教育年限、有无新生儿并发症方面差异具有统计学意义(P<0.05),两组产次、孕周、居住地差异无统计学意义(P>0.05);PPD组TSH、FT3、T3、T4、FT4水平均显著低于对照组,EPDS评分显著高于对照组,(P<0.05);PPD患者TSH、FT3、T3、T4、FT4水平与EPDS评分呈负相关,(P<0.05)。结论 PPD发生率较高,可能与甲状腺激素水平下降有关。
Abstract
[Abstract] Objective To investigate the relationship between postpartum depression (PPD) and thyroid hormone levels. Methods A total of 100 mothers from April 2020 to August 2022 in this study were selected. Depression was assessed using the Edinburgh Postpartum Depression Scale (EPDS). The groups were divided into PPD group and control group according to whether PPD was combined or not. The general information of the two groups was compared. Thyroid function indicators such as thyroid stimulating hormone (TSH), free triiodothyronine (FT3), triiodothyronine (T3), tetraiodothyronine (T4) and free thyroxine (FT4) were measured in both groups. The correlation between thyroid function indices and EPDS scores in patients with PPD was analyzed. Results Thirty-four of the 100 deliveries were complicated by PPD, and the differences between the PPD group and the control group in terms of age, years of education, and presence of neonatal complications were statistically significant (P<0.05). There was no statistically significant difference in the number of deliveries, gestational weeks, and place of residence between the two groups (P>0.05). TSH, FT3, T3, T4, and FT4 levels in the observation group were significantly lower than those in the control group, and EPDS scores were significantly higher than those in the control group (P<0.05). TSH, FT3, T3, T4, and FT4 levels in PPD patients were negatively correlated with EPDS scores (P<0.05). Conclusion The higher incidence of PPD may be related to decreased thyroid hormone levels.
关键词
关键词:产后抑郁;甲状腺激素;爱丁堡产后抑郁量表
KeyWord
Key words: postpartum depression; Thyroid hormone; Edinburgh Postnatal Depression Scale
基金项目
页码 1099-1101
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邓国良*. 产后抑郁与甲状腺激素水平的关系研究 [J]. 国际精神病学杂志. 2023; 50; (5). 1099 - 1101.

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