CircRNA调控脂代谢通路来影响肝癌的研究进展

The reseach progress of CircRNA regulatinglipid metabolic pathways to affect the hepatocellular carcinoma

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DOI 10.12208/j.jlsr.20230002
刊名
Journal of Modern Life Sciences Research
年,卷(期) 2023, 4(1)
作者
作者单位

上海健康医学院医学技术学院 上海 ;

摘要
中国是全球肝细胞癌(hepatocellular carcinoma, HCC)发病率最高的地区之一,其发病率与病死率均位居世界首位。影响肝癌的因素众多,其中脂代谢异常与肝癌的发展密切相关。许多研究证明CircRNA能够通过影响脂代谢通路关键酶、脂滴形成等进而影响肝癌的进展。本文就相关的最新研究进行综述,旨在开发以CircRNA 等为代表的早期有效标志物,为肝癌的早发现、早治疗提供依据。
Abstract
China is one of the areas with the highest incidence of hepatocellular carcinoma (HCC) in the world, and its incidence and mortality rates rank first in the world. There are many factors affecting hepatocellular carcinoma, among which abnormal lipid metabolism is closely related to the its development. Many evidence have proved that circRNA can affect the progression of liver cancer by affecting key enzymes in the lipid metabolism pathway, lipid droplet formation and et.al. This article reviews the latest related research, aiming to develop early effective markers represented by circRNA, to provide a basis for early detection and early treatment of liver cancer.
关键词
肝癌;脂代谢通路;CircRNA;标志物
KeyWord
hepatocellular carcinoma; lipid metabolism; CircRNA; biomarker
基金项目
页码 5-8
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樊榕,牛紫仪,嵇福森,闫涛,崔静怡,李钠*. CircRNA调控脂代谢通路来影响肝癌的研究进展 [J]. 现代生命科学研究. 2023; 4; (1). 5 - 8.

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