AMPK/NLRP3炎性小体轴在复发性流产的治疗靶点及策略-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

AMPK/NLRP3炎性小体轴在复发性流产的治疗靶点及策略

Therapeutic targets and Strategies of AMPK / NLRP3 inflammatory body axis in recurrent abortion

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DOI	10.12208/j.ijcr.20220160
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2022, 6(4)
作者	陈琳,冯强,程焱*,
作者单位	重庆南川区人民医院重庆 ;
摘要	分析AMPK/NLRP3炎性小体轴在复发性流产的治疗靶点及策略。方法将2021-03至2022-02在我院诊治的43例复发性流产患者，列为研究组；另选择同时间内来我院治疗的43例单次流产后正常妊娠者，纳入对照组。两组均接受AMPK/NLRP3炎性小体轴、白细胞介素-1β（IL-1β）、白细胞介素-18（IL-18）、Th17/Treg、Th1/Th2检测，对比两组的检测结果。结果研究组体内的AMPK/NLRP3炎性小体轴表达率显著高于对照组（P＜0.05）。在IL-1β、IL-18、Th17/Treg及Th1/Th2细胞上，研究组高于对照组（P＜0.05）。结论 AMPK/NLRP3炎性小体轴在复发性流产患者体内的表达率极高，可作为复发性流产的治疗靶点。
Abstract	Objective: To analyze the therapeutic targets and Strategies of AMPK / NLRP3 inflammatory body axis in recurrent abortion. Methods: 43 patients with recurrent abortion treated in our hospital from March 2021 to February 2022 were included in the study group; In addition, 43 cases of normal pregnancy after single Abortion Treated in our hospital at the same time were included in the control group. Both groups received AMPK / NLRP3 inflammatory body axis and interleukin-1 β (IL-1 β), Interleukin-18 (IL-18), Th17 / Treg and Th1 / Th2 were detected, and the test results of the two groups were compared. Results: the expression rate of AMPK / NLRP3 inflammatory body axis in the study group was significantly higher than that in the control group (P < 0.05). In IL-1 β, IL-18, Th17 / Treg and Th1 / Th2 cells in the study group were higher than those in the control group (P < 0.05). Conclusion: the expression rate of AMPK / NLRP3 inflammatory body axis in patients with recurrent abortion is very high, which can be used as a therapeutic target for recurrent abortion.
关键词	AMPK/NLRP3炎性小体轴；复发性流产；靶点治疗；策略
KeyWord	AMPK / NLRP3 Inflammatory Body Axis; Recurrent Abortion; Targeted Therapy; Strategy
基金项目
页码	72-74

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引用本文

陈琳,冯强,程焱*. AMPK/NLRP3炎性小体轴在复发性流产的治疗靶点及策略 [J]. 国际临床研究杂志. 2022; 6; (4). 72 - 74.

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