International Journal of Medicine and Data

Objective To investigate the protective effect of dexmedetomidine in patients with toxic brain injury during operation. Methods The so-called 100 cases of craniocerebral injury patients admitted to Nanyang Hospital in Henan Province from January 2021 to March 2023 were selected as the study object. The two groups of patients were divided into control group (n=50) and experimental group (n=50) in order of admission. Normal saline and dexmetomidine were respectively used in the two groups before anesthesia induction. On this basis, the anesthesia status and operation time of the two groups were compared. Results There was no significant difference in anesthesia time and operation time between the two patients, P>0.05. Compared with the control group, the dosage of remifentanil in experimental group kept up significantly during the operation, and the difference was significant (P<0.05). The two groups were compared in various recovery indexes at different time nodes, and there was no significant difference in the scores of the two groups at the end of the operation, P>0.05. At other time nodes, there were significant differences in various recovery indicators between the two groups (P<0.05). Conclusion The use of dextromedesensitization before anesthesia induction can effectively reduce the overall dosage of remifentanil in patients with cranial brain injury during surgery, which can form a good protection for the brain of patients, and also has a positive effect on the prognosis of patients with immune function, can achieve effective control of patients inflammatory response, and has a positive effect on the postoperative recovery of patients.

Craniocerebral injury; Dexmetomidine; Brain protection; Inflammatory response