International Journal of Clinical Research

Objective: To analyze the effect of platelet-derived growth factor (PDGF) on peripheral nerve regeneration in rats. Methods: A rat model of femoral implant was established. PDGF was injected continuously at the beginning of healing. The effect of PDGF on peripheral nerve regeneration was analyzed by immunohistochemistry (IHC) staining. Results: Under the action of PDGF, the number of nerve fibers around the femoral implant in rats increased at the initial stage, but it was not found that it significantly affected the number of nerve fibers around the implant at the later stage. In addition, these nerves have typical structures of peripheral nerve (PN) fibers. Conclusion: PDGF can effectively promote the peripheral nerve regeneration of implants. In order to realize the clinical application of PDGF to enhance peripheral nerve regeneration of implants, so as to effectively improve the sensory function of implants, this study provides some guidance at the experimental level.

Rat implant; Platelet derived growth factor; Peripheral nerve regeneration; influence