International Journal of Pediatrics Research

Objective To observe the efficacy of plasma exchange therapy in extremely severe hyperbilirubinemia. Methods Cases were 88 neonatal patients with extremely severe hyperbilirubinemia, and were recorded from May 2021 to June 2022. Conventional therapy group (44 patients): conventional therapy therapy. Plasmapheresis + conventional treatment group (44 patients): in addition to conventional therapy. research effect. Results A higher rate of excellent clinical condition control [95.46% (42 / 44), compared with 77.27% (34 / 44) in the conventional treatment group] (p <0.05). The total bilirubin concentration was lower after 3 and 5d [(255.17±51.39) umuo L / L, (215.39±45.16) umL / L, (348.17±74.11) umo L / L, (295.74 ± 65.18) umo L / L) in the conventional group) (p <0.05). The indirect bilirubin concentrations were lower after 3 and 5d [(244.09±48.05) umuo L / L, (217.25±40.39) umuo L / L versus (298.44±69.11) umo L / L, (268.33 ± 62.05) umo L / L), respectively) (p <0.05). The platelet concentration and blood glucose concentration after 5d [(243.15±1009 / L, (4.87±0.26) mmol/L, compared with (244.67±101.14) 109 / L, (4.8 3±0.15) mmol/L before treatment)] (p> 0.05). Conclusion For patients with very severe hyperbilirubinemia.

Extremely severe neonatal hyperbilirubinemia; Plasmapheresis therapy; Efficacy