International Medical Research Frontier

Objective To analyze the accuracy of intraoperative frozen pathological examination for the diagnosis of pulmonary nodules and provide effective basis for clinical treatment. Methods 135 cases of pulmonary nodules were selected from our hospital during the period of March 2022 to March 2023, which underwent surgical resection and intraoperative frozen pathological diagnosis. The results of intraoperative frozen pathological diagnosis, postoperative paraffin sections, and immunohistochemical pathological diagnosis were analyzed and compared. Results The accuracy of intraoperative frozen pathological examination in diagnosing benign and malignant pulmonary nodules was 98.52%. Out of 135 cases of pulmonary nodules, 2 cases were not clearly diagnosed. After surgery, paraffin sections were performed to diagnose 1 case as atypical adenomatous hyperplasia and 1 case as lung adenocarcinoma; The accuracy rate of intraoperative frozen pathological examination in diagnosing malignant lung lesions was 84.82%, with a higher diagnostic accuracy rate of 87.50% for lung adenocarcinoma. The diagnostic accuracy of neuroendocrine tumors is relatively low, at 66.67%. One case of metastatic cancer did not make a clear classification diagnosis; The accuracy rate of intraoperative frozen pathological examination in diagnosing benign lung lesions was 95.65%, and no specific classification diagnosis was made for one case of sclerosing pulmonary cell tumor. Conclusion The vast majority of benign and malignant pulmonary nodules can be accurately diagnosed through intraoperative frozen pathological examination. A small number of cases with difficulty in frozen diagnosis can be improved through reviewing medical history, combined with rapid immunohistochemistry technology, etc., to improve the diagnostic efficiency of intraoperative frozen pathological examination and provide effective basis for adjusting surgical plans.

Pulmonary nodules; Intraoperative frozen pathology; Diagnostic analysis