植物源细胞外囊泡在炎症性肠病治疗中的应用-现代生物技术研究-CSCIED科技核心评价数据库-手机版

植物源细胞外囊泡在炎症性肠病治疗中的应用

Application of plant-derived extracellular vesicles in the treatment of inflammatory bowel disease

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DOI	10.12208/j.jmbr.20230002
刊名	现代生物技术研究 Journal of Modern Biotechnology Research
年，卷(期)	2023, 1(1)
作者	蔡鹏¹,张明真²,高博雯²*,
作者单位	1 新疆莎车县 69218 部队医院新疆喀什 ; 2 西安交通大学基础医学院医学工程研究所陕西西安 ;
摘要	炎症性肠病（inflammatory bowel disease, IBD）是一种慢性非特异性的肠道炎症性疾病。目前临床常用的化学治疗药物和免疫抑制剂会对患者产生较大的副作用，新型的免疫疗法也存在治疗效果个体差异大等问题，因此开发IBD治疗新方式具有重要意义。细胞外囊泡（EVs）是一种异构的磷脂双层封闭的生物颗粒，几乎所有的活细胞都能分泌EVs，包括植物细胞。植物源性细胞外囊泡（PDEVs）是从植物中分离出来的囊泡状纳米结构颗粒的总称。研究发现，多种PDEVs具有良好的稳定性，口服后能够穿过胃肠道的生理环境到达结肠，并且在炎症性肠病模型中显示出优良的结肠靶向性和滞留性。此外，PDEVs可作为一种脂质体实现药物递送，有望实现IBD多种药物的联合治疗。与动物源细胞外囊泡相比，低免疫原性和广泛的可获得性使得PDEVs作为治疗药物和药物载体更安全、更经济。因此，PDEVs作为一种新的治疗方法，在炎症性肠病的治疗领域展现出巨大的应用潜力。在本文中，我们回顾了目前关于PDEVs的知识，总结了PDEVs作为一种IBD治疗新方法的潜在应用。
Abstract	Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory bowel disease. Currently, chemotherapy drugs and immunosuppressants commonly used in clinical practice may cause great side effects to patients, and new immunotherapies also have problems such as large individual differences in therapeutic effect. Therefore, it is of great significance to develop new therapeutic methods for IBD. Extracellular vesicles (EVs) are heterogeneous, bilayer sealed biological granules of phospholipids that are secreted by almost all living cells, including plant cells. Plant-derived Extracellular vesicles (PDEVs) are a general term for vesicle-like nanostructured particles isolated from plants. Multiple PDEVs have been found to be stable, able to cross the physiological environment of the gastrointestinal tract and reach the colon after oral administration, and show excellent colonic targeting and retention in inflammatory bowel disease models. In addition, PDEVs can be used as a liposome to achieve drug delivery, which is expected to realize the combination therapy of multiple drugs for IBD. Their low immunogenicity and widespread availability make PDEVs safer and more economical as therapeutic agents and drug carriers than animal-derived extracellular vesicles. Therefore, PDEVs, as a new therapeutic method, has shown great application potential in the treatment of inflammatory bowel disease. In this article, we review current knowledge about PDEVs and summarize the potential application of PDEVs as a new therapeutic approach for patients with IBD.
关键词	植物；细胞外囊泡；炎症性肠病；治疗
KeyWord	Plant; Extracellular Vesicles; Inflammatory Bowel Disease; Treatment
基金项目
页码	6-11

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引用本文

蔡鹏,张明真,高博雯*. 植物源细胞外囊泡在炎症性肠病治疗中的应用 [J]. 现代生物技术研究. 2023; 1; (1). 6 - 11.

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