白花败酱草对牙周炎小鼠的抗炎作用-国际医学与数据杂志-CSCIED科技核心评价数据库-手机版

白花败酱草对牙周炎小鼠的抗炎作用

Anti-inflammatory effect of Patrinia alba on mice with periodontitis

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DOI	10.12208/j.ijmd.20230105
刊名	国际医学与数据杂志 International Journal of Medicine and Data
年，卷(期)	2023, 7(7)
作者	冼桂羽,郭振宇,秦依雯,夏明珠,卿即娜*,
作者单位	长沙医学院口腔医学院湖南长沙 ;
摘要	探究白花败酱草水煎剂对牙周炎小鼠血清中炎症因子C反应蛋白（CRP）、白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）含量的影响。方法将50只C57BL/6小鼠随机分为空白对照组、牙周炎阳性对照组、白花败酱草低、中、高剂量组，每组十只，共五组，将后四组进行牙周炎建模进行实验。利用酶联免疫法（Elisa）进行检测，采用SPSS20.0统计学软件分析所得结果，比较不给药和给药不同浓度白花败酱草药物下小鼠血清中该三种炎症因子的含量。结果与牙周炎阳性对照组相比，白花败酱草水煎剂对各组低、中和高剂量组小鼠的牙周炎炎症有抑制作用；不同的服用药量对牙周炎小鼠炎症均有抑制作用，与服用剂量呈正相关，其中，白花败酱草高剂量组的CRP水平为16.21±1.95mg/L，IL-6水平为33.21±3.05pg/ml，TNF-α水平为10.65±5.58pg/mg，与阳性对照组相比，三组给药组均为p＜0.05。结论白花败酱草可降低牙周炎小鼠血清中炎症因子含量，对牙周炎小鼠的抗炎发挥一定的作用。
Abstract	Objective To investigate the effects of water decoction of Patrinia alba on the content of inflammatory factor C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in serum of mice with periodontitis. Methods Fifty C57BL/6 mice were randomly divided into five groups, including blank control group, periodontitis positive control group, low, medium and high dose groups with ten mice in each group, and the last four groups were subjected to periodontitis modeling. Enzyme-linked immunoassay (Elisa) was used to detect the three inflammatory factors, and the results were analyzed by SPSS20.0 statistical software. The contents of the three inflammatory factors in the serum of mice were compared between those treated with no medication and those treated with different concentrations of Patrinia. Results Compared with the periodontitis positive control group, the water decoction of Parazepia alba could inhibit the periodontitis inflammation of mice in low, medium and high dose groups. Different dosages inhibited the inflammation of periodontitis mice, and were positively correlated with dosages. In the high-dose group, CRP level was 16.21±1.95mg/L, IL-6 level was 33.21±3.05pg/ml, and TNF-α level was 10.65±5.58pg/mg. Compared with the positive control group, p < 0.05 was observed in all three groups. Conclusion The content of inflammatory factors in serum of mice with periodontitis can be decreased, and the anti-inflammation of mice with periodontitis can be achieved.
关键词	牙周炎；白花败酱草；CRP；IL-6；TNF-α
KeyWord	Periodontitis; Patrinia alba; CRP; IL-6; TNF alpha
基金项目
页码	1-4

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引用本文

冼桂羽,郭振宇,秦依雯,夏明珠,卿即娜*. 白花败酱草对牙周炎小鼠的抗炎作用 [J]. 国际医学与数据杂志. 2023; 7; (7). 1 - 4.

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