International Journal of Clinical Research

Objective To evaluate the clinical effect of autologous skin grafting combined with negative pressure closed drainage in the treatment of refractory chronic venous ulcer of lower extremities. Methods The clinical data of 20 patients with refractory chronic venous ulcer of lower extremity were analyzed retrospectively. 10 patients received autologous skin transplantation combined with negative pressure closed drainage (treatment group), and the other 10 patients received traditional autologous skin transplantation (control group). The healing time, healing rate and complications of the two groups were compared, and statistical analysis was performed. Results The average healing time of the treatment group was (13.5±3.2) weeks, and the average healing time of the control group was (17.8±4.5) weeks, the difference between the two groups was statistically significant (P<0.05). The healing rate of the treatment group was 90%, and that of the control group was 70%, the difference between the two groups was statistically significant (P<0.05). The incidence of complications was 20% in the treatment group and 40% in the control group, and the difference between the two groups was statistically significant (P<0.05). Conclusion Autologous skin transplantation combined with negative pressure closed drainage is an effective method for the treatment of refractory chronic venous ulcer of lower extremities, which has a shorter healing time and a higher healing rate, and reduces the occurrence of complications.

Autologous skin grafting; Negative pressure closed drainage technology; Refractory chronic venous ulcer of lower extremity; Clinical effect