International Journal of Clinical Research

Objective To explore the improvement effect of high-throughput dialysis on renal anemia in patients with maintenance hemodialysis. Methods From January 2021 to October 2022, 80 patients with maintenance hemodialysis for renal anemia were selected. Design the controlled study, the digital table method divided the included patients into 2 groups, 40 patients / group. The control group underwent low-throughput dialysis, and the observation group underwent high-throughput dialysis. Comparing the incidence of adverse effects in both groups and the anemia indicators before and after treatment [hemoglobin (hemoglobin, Hb), red BC rit (hematocrit, Hct), recombinant human erythropoietin (Recombinant human erythropoietin, And r-HuEPO) / Hct], inflammatory factor [hypersensitive C-reactive protein (hypersensitive C-reactive protein, hs-CRP), interleukin-6 (interleukin-6, IL-6)]. Results For adverse reactions, the incidence of muscle soreness in the observation group was 0.00%, which was lower than that in the control group (χ2=4.2105; P <0.05). Among the anemia indicators, post posttreatment Hb levels were (115.94 ± 15.43) g / L and Hct levels (29.87 ± 3.43), higher than the control group (T=6.8813; T=3.9857; P <0.05); the r-HuEPO / Hct level was (2.08 ± 0.22) * 104 U and lower than the control group (T=8.7277; P <0.05). Among the inflammatory factors, the hs-CRP levels were (12.14 ± 2.72) mg/L and IL-6 were (1.06 ± 0.32) pg/mL, which were lower than those in the control group (P <0.05). Conclusion In the treatment of renal anemia on maintenance hemodialysis, high-throughput dialysis can effectively improve the state of renal anemia, reduce the inflammation level of the body, and reduce muscle pain, which is worth promoting.

Maintenance hemodialysis renal anemia; High-throughput dialysis; incidence of adverse reactions; Anemia index; Inflammatory factors