有关喉鳞状细胞癌生物标志物的研究进展

Research progress on biomarkers of laryngeal squamous cell carcinoma

ES评分 0

DOI 10.12208/j.ijcr.20230357
刊名
International Journal of Clinical Research
年,卷(期) 2023, 7(12)
作者
作者单位

佳木斯大学附属第一医院 黑龙江佳木斯 ;

摘要
喉癌属于头颈部较为常见的癌症种类之一,90%的病例均属于鳞状细胞癌(SCC)。鳞状细胞癌在临床中较为明显的病理主要表现包括侵入性增长,早期的淋巴结扩散和局部的侵犯,这些都是引起其治愈后再次出现和扩散的关键因素,对患者的长期治愈与生存期产生了影响。目前,对于喉癌的治疗方式主要依赖于手术切除病理组织。然而在实际的医疗过程中,大多数的喉癌患者都处于晚期阶段,这为患者的治疗以及预后带来了巨大的挑战。对喉癌的准确识别、及时的医疗干预、疾病的跟踪以及预后评估,都离不开高效的生物指示物。本文主要讨论了近些年来与喉癌相关的生物指示物的研究发展,涵盖基因、基质金属蛋白酶、细胞因子、非编码RNA以及外泌体五个领域。
Abstract
Laryngeal cancer is one of the most common types of cancer in the head and neck, with 90% of cases belonging to squamous cell carcinoma (SCC). The main pathological manifestations of squamous cell carcinoma in clinical practice include invasive growth, early lymph node spread, and local invasion, which are key factors causing its recurrence and spread after cure, and have an impact on the long-term cure and survival of patients. At present, the treatment for laryngeal cancer mainly relies on surgical removal of pathological tissue. However, in the actual medical process, most laryngeal cancer patients are in the advanced stage, which poses great challenges to their treatment and prognosis. Accurate identification, timely medical intervention, disease tracking, and prognosis evaluation of laryngeal cancer all rely on efficient biological indicators. This article mainly discusses the research and development of biological indicators related to laryngeal cancer in recent years, covering five fields: genes, matrix metalloproteinases, cytokines, non coding RNA, and exosomes.
关键词
喉鳞状细胞癌;标志物;miRNA;lncRNA
KeyWord
Laryngeal squamous cell carcinoma; Markers; miRNA; lncRNA
基金项目
页码 9-12
  • 参考文献
  • 相关文献
  • 引用本文

杨旭,张美佳*. 有关喉鳞状细胞癌生物标志物的研究进展 [J]. 国际临床研究杂志. 2023; 7; (12). 9 - 12.

  • 文献评论

相关学者

相关机构