International Journal of Clinical Research

Objective We select the physical examination population for early screening of liver fibrosis and fatty liver in Chibi City, and explore the risk factors of liver fibrosis and fatty liver in the physical examination population through analysis of physical examination data and behavioral lifestyle data, in order to provide a basis for health departments and governments to prevent liver fibrosis and fatty liver. Methods A questionnaire survey and related index examinations were conducted on 1443 physical examination population. Questionnaire survey: mainly investigate the demography (such as age and gender), behavior and lifestyle (such as dietary habits, physical exercise, smoking and drinking habits, and past medical history) of the physical examination population. Observation indicators: Body mass index (height and weight), total cholesterol, triglyceride, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and other indicators about liver stiffness, and liver fat attenuation were mainly measured. Correlation analysis, risk factor analysis, and prediction models are performed on the degree of liver fibrosis and fatty liver. Results Univariate analysis showed that gender (male), age, body mass index, triglyceride, exercise, smoking, drinking, hypertension, diabetes, dyslipidemia were statistically significant in relation to liver fibrosis (P<0.05). Among them, body mass index showed significant differences in different degrees of liver fibrosis. Gender, age, body mass index, total cholesterol, triglycerides, low-density lipoprotein (LDL-C), oily food, smoking, drinking, hypertension, diabetes, and dyslipidemia were statistically significant for fatty liver (P<0.05). Among them, body mass index and triglycerides have significant differences with different degrees of fatty liver. Multiple logistic regression analysis showed that male (OR=1.798, OR95%CI=1.175-2.752), age (OR=1.041, OR95%CI=1.028-1.054), increased body mass index (OR=1.329, OR95%CI=1.264-1.399) were independent risk factors for liver fibrosis. Male (OR=2.201, OR95%CI=1.467-3.303), age (OR=1.013, OR95%CI=1.001-1.025), increased body mass index (OR=1.518, OR95%CI=1.476-1.693), abnormal triglycerides (OR=1.874, OR95%CI=1.528-2.288) were independent risk factors for fatty liver. The multivariable models showed good predictive performance for both liver fibrosis and fatty liver abnormalities in patients. Conclusion Male, age, obesity and diabetes were independent risk factors for liver fibrosis. Male, age, obesity and abnormal triglycerides were independent risk factors for fatty liver.

Liver fibrosis；Fatty liver；Risk factors