International Journal of Obstetrics and Gynecology

Objective To investigate the predictive value of serum βHCG increase in early pregnancy outcome in IVF-ET. Methods A total of 126 patients with IVF-ET were selected and divided into groups according to pregnancy outcomes. The correlation between the average daily increase of serum βHCG during 14 to 21 days of embryo transfer and the outcome of early pregnancy was retrospectively analyzed. ROC curves were used to determine the cut-off points for the mean increase in βHCG within 14 to 21 days after embryo transfer for different pregnancy outcomes. Results (1) Most of the biochemical pregnancy groups had negative growth; (2) The critical point of ROC curve for diagnosing persistent and non-persistent pregnancy was 665.45 mIU/ml/day, with a sensitivity of 0.81 and a specificity of 0.79; (3) ROC curve for the diagnosis of singleton The critical point of continuous pregnancy and twin pregnancy is 2017.97mIU/ml/day, the sensitivity is 0.78, the specificity is 0.72; (4) The critical point of ROC curve for the diagnosis of singleton continuous pregnancy and adverse pregnancy is 602.66mIU/ml/day, the sensitivity is 0.83, The specificity was 0.65. Conclusion During 14 to 21 days after embryo transfer, the average daily increase rate of βHCG can predict biochemical pregnancy and normal persistent pregnancy. It is of certain clinical significance to distinguish single pregnancy from twin persistent pregnancy, and to judge the outcome of early pregnancy.

βHCG; embryo transfer; pregnancy outcome